University of Alabama at Birmingham
1825 University Boulevard
Shelby Bldg, Room 1070
Birmingham, AL  35294

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What Our Lab Does

  • Our interest is in understanding the molecular mechanisms underlying learning and memory.
     
  • For the last two decades my laboratory has been investigating the biochemical mechanisms subserving the induction and maintenance of long-term potentiation (LTP) in the hippocampus and underlying memory formation in the behaving animal.
     
  • We use both pharmacologic and genetic experimental manipulations to investigate the molecular basis of normal learning and the biochemical derangements that underlie pathological conditions affecting learning and memory.
     
  • Our future scientific goal is to capitalize upon our recent insights into the signal transduction mechanisms operating in hippocampal synaptic plasticity in order to develop new treatments for memory disorders.

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Sultan, et al

Zovkic, et al

 Sweatt, JD

Genetic deletion of Gadd45b enhances long-term memory and synaptic plasticity

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Epigenetic regulation of memory formation and maintenance

 

Pitt-Hopkins Syndrome: intellectual disability due to loss of TCF4-regulated gene transcription

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